Effect of Apolipoprotein E on the Prognosis of Patients With Intracerebral Hemorrhage

The purpose of this observational study was to compare perihematomal edema and short-term prognosis in patients with intracerebral hemorrhage carrying the APOE-ε3 and APOE-ε4 genes. The main questions it aims to answer are:Exploring whether patients carrying the ApoE-ε4 gene have more perifocal perihematomal edema after intracerebral hemorrhage than patients with the ApoE-ε3 gene.ApoEε4 gene has worse short-term prognosis than ApoEε3 gene in intracerebral hemorrhage patients.All the patients in this study received the same medications based on the guidelines for the management of hypertensive intracerebral hemorrhage.Some ICH patients were evaluated for Stereotactic minimally invasive surgery (sMIS) treatment by two experienced neurosurgeons.

Inclusion Criteria:Diagnosis of ICH confirmed by non-enhanced CT scan.ICH volume less than 85ml.The apolipoprotein genotypes of the patients were APOE-ε3 and APOE-ε4 by venous blood sampling.Exclusion Criteria:Patients with ICH due to trauma, anticoagulation therapy, or antiplatelet therapy were excluded.The patients with ICH volume greater than 85 ml were excluded.Admission with diseases that may affect the inflammatory response, such as: infectious meningitis, systemic infections, etc.Stroke patients with previous residual neurological deficits.