Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders Among Hospitalized Patients

The goal of this clinical trial is to test the effectiveness of an integrated infectious disease/substance use disorder (SUD) clinical team intervention approach in patients hospitalized with severe injection-related infections (SIRI) who use drugs. The main question this study aims to answer is whether this intervention approach will be associated with lower mortality and fewer hospital readmissions. Participants will participate in the integrated SUD/ID care team intervention (SIRI Team). Researchers will compare this intervention to treatment as usual (TUA) to see if there are any differences in health outcomes.

Inclusion Criteria:Be admitted to a participating hospital at the time of randomizationBe 18 years of age or olderCurrently be experiencing a severe injection-related infection/SIRIHave an indication of injecting drugs in the prior yearProvide informed consentAbility to communicate in English or SpanishProvide sufficient locator informationSign a HIPAA form and/or EHR release to facilitate record abstractionReport being willing to return for follow-up visitsExclusion Criteria:All individuals meeting any of the exclusion criteria will be excluded from study participation. Specifically, individuals will be excluded from participation if they:have significant cognitive or developmental impairment to the extent that they are unable to provide informed consent(or their legal guardian/representative) are unable or unwilling to give written informed consentare currently in jail, prison or other overnight facility as required by court of law or have pending legal action that could prevent participation in study activitiesare terminated via site principal investigator decision with agreement from one of the study lead investigators.