Effect of MRA on Cardiovascular Disease in Patients With Hypertension and Hyperaldosteronemia

Elevated aldosterone causes moderate to severe increase in blood pressure, and leads to various target organ damage including cardiovascular ones. Aldosterone has been considered one of the important risk factors for cardiovascular and cerebrovascular diseases. Currently, the use of mineralocorticoid receptor antagonists(MRA) has been proven to reduce blood pressure levels, but long-term prognostic data are lacking in hypertensive patients. Therefore, the purpose of this clinical trial is to assess the effect of MRA on cardiovascular disease in patients with Hypertension and Hyperaldosteronemia.

Inclusion Criteria:Age: 18-75 years old;Blood pressure ≥140/90 mmHg, or have taken antihypertensive drugs;Plasma aldosterone concentration> 12ng/ dL;Serum potassium < 4.8mmol/L;Signed the written informed consent.Exclusion Criteria:SBP/DBP≥190/120mmHg, DBP<60 mmHg;Known secondary cause of hypertension, including pheochromocytoma, primary aldosteronism (adrenal tumor > 1cm), Cushing's syndrome, renal artery stenosis, renin tumor, connotation of aorta, etc.;History of ischemic or hemorrhagic stroke within the last 3 months (not lacunar infarction and transient ischemic attack [TIA]).History of Hospitalization for myocardial infarction or unstable angina, or coronary revascularization (PCI or CABG) within the last 3 months.History of aortic dissection/dissection aneurysm rupture.History of NYHA Grade III-IV heart failure or hospitalization Aggravated chronic heart failure upon admission within the last 3 months.A history of persistent atrial fibrillation, atrial flutter, or other severe arrhythmias on admission (including sinus delay, diseased sinus, high atrioventricular block, frequent ventricular morning, etc.).Severe liver disease or liver dysfunction: AST, ALT, or ALP > 5ULN (5 times the upper limit of normal), or BIL > 3ULN (3 times the upper limit of normal).End-stage renal disease (ESRD) on dialysis, or estimated glomerular filtration rate (eGFR) <30 mL/min, or serum creatine >2.5 mg/dl [>221 umol/L];Patients with serious physical diseases such as malignant tumors and autoimmune diseases.Severe cognitive or mental impairment.Pregnant and lactating women.Those who have contraindications or allergies to MRAs.Patients with hypoadrenocortical function.Participating in other clinical trials.