Dietary Antioxidants and Thiol Disulfide Homeostasis in T2DM

This observational study was planned to determine the relationship between dietary antioxidant intake and thiol disulfide homeostasis of individuals with type 2 diabetes. One of the current approaches in medical nutrition therapy of diabetes is to increase the consumption of foods with high antioxidant content in order to strengthen antioxidant defense. Increased dietary antioxidant intake may have both protective and therapeutic effects by reducing the risk of diabetes and preventing complications that may occur. It is known that dynamic thiol disulfide balance can be a good indicator of antioxidant defense in individuals with diabetes, and there are limited studies on this subject.

Inclusion Criteria (for case group):Diagnosis with type 2 diabetes mellitusDiabetes age for a maximum of 5 yearsBody mass index (BMI)<30 kg/m^2Received and applied medical nutrition therapy and metformin therapyInclusion Criteria (for control group):Body mass index (BMI) <30 kg/m^2Exclusion Criteria (for case group):Receiving insulin therapyDeveloping diabetes-specific complicationsSmoking tobaccoConsuming alcoholHaving end-stage chronic renal failureReceiving chemotherapy and/or radiotherapyBeing in menopause, pregnant and/or lactation periodUsing antioxidant vitamin and mineral supplementsExclusion Criteria (for control group):Smoking tobaccoUsing alcoholHaving any chronic diseaseHaving end-stage chronic renal failureReceiving chemotherapy and/or radiotherapyBeing in menopausal, pregnant and/or lactation period,Using antioxidant vitamin and mineral supplementsFollowing any diet program