Intravenous Nalbuphine Versus Intravenous Dexmedetomidine for Conscious Sedation in Patients Undergoing Colonoscopy

The aim of this study is to compare the sedative, analgesic effect and hemodynamic changes due to dexmedetomidine and nalbuphine during elective colonoscopy.

Inclusion Criteria:The subject is scheduled for elective colonoscopy.The subject is ≥ 18 years and ≤ 80 years.Both sexes.No obvious abnormalities in preoperative ECG, blood routine ,electrolytes, and other tests .ASA class 1-3.Exclusion Criteria:Subject is known or believed to be pregnant or lactating women.Patients allergic to α2-adrenergic agonist or sulfa drugsChronic Opioid Use (daily or almost daily use of opioids for > 3 months).Patients that are immunologically compromised, or receiving chronic steroids (>30 days), excluding inhalers.Sleep apnea syndrome or difficult airway.Patient known to be asthmatic or recent chest infection.Patients that are prisoners.Patient refusal.