The Influence of Ketogenic Diet on Lupus Nephritis Patients' Immunity

The study investigates the dietary habits in relation to low doses of omega-3 fatty acids in subcutaneous adipose tissue, disease activity and atherosclerosis. The low intake of omega-3 and high intake of carbohydrate among patients with SLE appear to be associated with worse disease activity, adverse serum lipids and plaque presence.Three-month-old mice received an injection of pristane or saline solution and were fed with different experimental diets: sunflower oil diet or extra virgin olive oil (EVOO) diet. After 24 weeks, mice were sacrificed, spleens were collected and kidneys were removed for immunoinflammatory detections. The study have demonstrated that EVOO diet significantly reduced renal damage and decreased cytokine: TNF-α, IL-6, IL-10 and IL-17 production.The ketogenic diet utilizes a high fat, adequate protein, low carbohydrate diet that control type of food and exchange. The aim of the present study that ketogenic diet treated in SLE patients may decrease overactive immunity and associated inflammatory markers.

Inclusion Criteria:more than 20 years oldcan accept these dietary intervention and fill out the consentSatisfy at least four criteria according to 1997 American College of Rheumatology Classification CriteriaUnder maintenance stage of disease and have more than 1gm of daily proteinuria.Exclusion Criteria:Can't cooperate the diet interventionRapid progression of renal function, or already need renal replacement therapy (Dialysis or kidney transplantation)