Optimizing Vancomycin Therapy in Children

The purpose of Opt Vanc is to evaluate the feasibility of Bayesian dose adaptation, based on a previously-developed population pharmacokinetic (PK) model and a single optimally timed PK sample, to predict vancomycin area under the curve (AUC) in critically ill children.

Inclusion Criteria:Administered intravenous vancomycin via intermittent infusion,Eligible for vancomycin AUC monitoring, per the subject's clinical team, andParental/guardian permission (informed consent).Exclusion Criteria:Receipt of renal replacement therapy, plasmapheresis, or extracorporeal membrane oxygenation (ECMO), orUnable to provide urine and blood samples.