Discovering Novel Cancer Treatment Options Using a Comprehensive NGS-based Molecular Testing Panel in the Community Setting ("DINOSAur")

To prospectively identify cancer patients whose tumors express specific molecular markers targeted by therapeutic agents from a comprehensive molecular test, for the purpose of selecting the most clinically appropriate treatment in a pragmatic two arm trial.

Inclusion Criteria:Patients who have given informed consent in accordance with the methods and procedures of this studyDiagnosis of cancer (stage 3 and stage 4; solid tumors only) requiring medical carePatients who have not received treatment related to his/her cancerPatients who are willing to sign a release of medical records to the research teamMale and female patients ≥18 years of agePatients under oncology care of a participating siteSufficient clinical status for collection of biospecimen samples within usual carePatients who have insurance coverage for CMTExclusion Criteria:Patients considered minors in the jurisdiction where the protocol is conducted.Patients who are prisoners and pregnant women.Patients who cannot provide consent and did not sign a power of attorney.