MRI and Biomarkers for Lung Nodules Detected During Lung Cancer Screening

The primary objective of this pilot observational study is to evaluate the accrual and retention rate of a study population from a centralized lung cancer screening program to support MRI and blood-based biomarker research for lung cancer screening.

Inclusion Criteria:Ability to read and understand informed consentMale or female adults who are at high risk for lung cancer and are enrolled in the centralized lung cancer screening program: Based on USPSTF guidelines: Age 50-80 with 20 or greater pack-year smoking story who continue to smoke or quit within the past 15 years without sign or symptoms of lung cancer. Or based on National Comprehensive Cancer Network (NCCN) guidelines but do not meet the USPSTF guidelines, age 50-unlimitedFound to have one or more lung nodules that is 6mm or greater on screening LDCTExclusion Criteria:Persons with an active diagnosis of cancerPersons with active signs or symptoms of lung cancerPersons with mechanically, magnetically, or electrically activated implants, such as cardiac pacemakers, neurostimulators, and infusion pumps.Persons with ferromagnetic implants and ferromagnetic foreign bodies, such as intracranial aneurysm clips, shrapnel and intraocular metal chips as these could become dislodged.Persons who are pregnant, nursing, are implanted with intrauterine devices (IUD's) that are not MR-compatiblePersons unable to tolerate MRI imaging secondary to an inability to lie supine or severe claustrophobia.Persons who are non-compliant with visit instructions, including inability to lie still, hold breath or follow procedure instructions