Opium Tincture Against Chronic Diarrhea

Inclusion Criteria:Signed informed consent before any study specific proceduresAble to read and understand DanishMale or female with an age of 20 years or moreThe researcher believes that the participant understands what the study entails, are capable of following instructions, can attend when needed, and are expected to complete the study.The investigator will ensure that fertile female participants have a negative pregnancy test before each treatment visit and use contraception during the entity of the study.Opioid naïve (in this study "opioid naïve" is defined as a person who does not have a history of opioid use/addiction. If the opioids were used more than five years before the start of experiment as an analgesic to treat pain post-surgery etc., this person will be considered opioid naïve. If the person has never used opioids to treat pain but has participated in pain studies where opioids were given more than a year before this experiment, this person will be considered opioid naïve)Healthy (assessed by a study-affiliated medical doctor)Exclusion Criteria:Known allergy towards pharmaceutical compounds similar to Dropizol.Participation in other studies within 14 days of first visit (1 year if opioids involved).Expected need of medical/surgical treatment during the studyHistory of psychiatric illness (e.g. mental retardation, schizophrenia, affective disorders (depression), personality disorders or treatment with psychoactive medications)History of substance abuse (e.g. alcohol, nicotine, tetrahydrocannabinol (THC), benzodiazepine, central stimulants and/or opioids)Family history of substance abuseKnown increased intracranial pressureKnown major stenosis of the intestinesPlanned MRI within the next 3 monthsMetal implants or pacemakerKnown severe decreased renal function (defined as estimated glomerular filtration rate (eGFR) below 45)Known severe decreased hepatic function (defined as Child-Pugh class B or higher)Treatment with Monoamine oxidase (MAO) inhibitors during the entity of the studyKnown severe chronic obstructive pulmonary disease (COPD) or acute severe asthma (defined as forced expiratory volume in 1 second (FEV1) below 50 % or acute ongoing exacerbation)Known cor pulmonaleFemale participants that are lactatingMedicine known to affect gastrointestinal motility must not be initiated during the entity of the studyUse of any analgesic medication within 48 hours before start as well as for the duration of the study (urine drug test will be performed prior to treatment start).Intake of alcohol within 48 hours before start of study period as well as for the duration of the study.

Source: ClinicalTrials.gov (NCT05702190). StuddyBuddy aggregates publicly available trial information.

Opium Tincture Against Chronic Diarrhea - Healthy

Summary

Eligibility Criteria