Imaging the Pathogenesis of Cerebral Small Vessel Disease

Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.

Inclusion Criteria:Clinical or radiographic evidence of ischemic strokeOne vascular risk factor (hypertension, hyperlipidemia, or diabetes)Evidence of cerebral small vessel disease on MRIExclusion Criteria:Inability to complete 3 research MRI scans over 1.25 years