Visual Processing Speed and Objective Analysis of Ocular Movements in Multiple Sclerosis

Conditions: Multiple Sclerosis, Clinically Isolated Syndrome, Relapsing Remitting Multiple Sclerosis, Progressive Multiple Sclerosis

Sex: All

Ages: 18 Years – 80 Years

Healthy volunteers: 1

Enrollment: 120

Sponsor: Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA

Summary

This project aims to analyze ocular motility problems, visual processing speed and microperimetry, and their relationship with consolidated retinal structural biomarkers (optical coherence tomography, OCT) in patients with Multiple Sclerosis w/w reading complaints comparing with healthy subjects.

Eligibility Criteria

Inclusion Criteria:Diagnosis of Multiple SclerosisBest distant corrected visual acuity equal or greater than 0.7 (decimal scale). Glasses or soft contact lenses users.Best close corrected visual acuity equal to or greater than 20/30 (Snellen scale).Glasses or soft contact lenses users.Exclusion Criteria:Patients with a history of acute optic neuritis (ON) and/or who experienced an episode of ON <6 months prior to the study, to avoid potential interference of papilledema with accurate peripapillary RNFL thickness measurements.Patients with other retinal and optic nerve diseases, advanced cataracts according to the international Lens Opacities Classification System III (LOCS III) (opacities greater than C2N2)Patients with other ophthalmological diseases that could affect central visual acuitySubjects with high refractive error (+ - 6 diopters).Subjects with other demyelinating disorders (neuromyelitis optica or acute disseminated encephalomyelitis).

Source: ClinicalTrials.gov (NCT05706220). StuddyBuddy aggregates publicly available trial information.