Comparison of Different Walk and Performance Test in Detecting Silent Hypoxia

Conditions: Hypoxia, COVID-19 Pneumonia, Oxygen Saturation, Pulmonary Rehabilitation

Summary

Healthcare systems around the world have been dealing with COVID 19. One of the main manifestations of this infection is lung involvement of varying degrees, causing a spectrum of diseases from mild lower respiratory tract infection to severe Adult Respiratory Distress Syndrome (ARDS). One of the important clinical parameters is to detect hypoxia early in order to initiate a higher level of care at the earliest. The presence of silent or latent hypoxia has made this task difficult in COVID 19. Besides, critical findings such as silent hypoxia that is not at rest but triggered by effort can be revealed by some practical field tests such as the 6-minute walk test or the 1-minute chair sit and stand test. Moreover, these simple tools also help to investigate the patient's readiness for discharge. In this way, it will be useful to evaluate their usability in discharge decisions or in determining the post-discharge cardiopulmonary reserves of the patients and therefore their rehabilitation needs. Although walk and performance tests can be performed naturally, safely and simply, more similarly to movements in daily living activities compared to cardiopulmonary exercise tests, the interest in these tests has increased over the years, especially in subjects such as exercise capacity, mortality and morbidity expectation, or oxygen desaturation in patients with chronic cardiopulmonary pathology. The number of studies in 19 patients is quite limited. For this reason, the necessity of new studies on different field tests to detect the presence of latent hypoxia, which expresses the oxygen desaturation triggered by effort, and to evaluate the exercise tolerance status before discharge, has been emphasized in recent reviews.The aim of this study is to determine the presence of silent hypoxia, which expresses the oxygen desaturation triggered by effort, in Covid-19 patients and to compare the different short-term walk and performance tests, which the investigators consider easier and applicable in the conditions of the pandemic environment, with the classical gold standard test ( Six minute walk test) in order to evaluate the exercise tolerance status of the patients before discharge.

Eligibility Criteria

Inclusion Criteria:Patients with a diagnosis of covid 19 between the ages of 18-80Patients with a SaO2 value > 93 in room airPatients who do not have dyspnea symptoms in room air during restPatients whose breathing frequence < 21 at restPatients who can walk independently and get up from their seatPatients who did not receive any rehabilitationPatients who can cooperate and who are fully orientedPatients who volunteered to participate in the studyExclusion Criteria:Severe pnemonia due to Covid-19Exacerbation, severe respiratory failure (resting partial pressure of oxygen in standard ambient conditions of less than 55 mmHg), and inability or unwillingness to understand or comply with the study protocol.Unable to walk unaidedPatients diagnosed with vertigo, Meniere, etc. balance disorder and dizzinessPatients diagnosed with orthostatic hypotensionPatients diagnosed with neurologic disease such as: stroke, ms-like neuromotor pathologypregnant women and those diagnosed with epilepsyPatients with BMI > 35Patients with problems in cooperation

Source: ClinicalTrials.gov (NCT05709262). StuddyBuddy aggregates publicly available trial information.