the Effects of Platelet-Rich Plasma on Postoperative Complications After Meningomyelocele

Conditions: Meningomyelocele/Spina Bifida

Sex: All

Ages: 1 Day – 1 Month

Healthy volunteers: 1

Phase: NA

Enrollment: 40

Sponsor: Yuzuncu Yıl University

Location: Turkey

Summary

Introduction: Meningomyelocele is a common congenital neural tube defect. To reduce complications, early surgery and a multidisciplinary approach is needed. In this study, the investigators administered platelet-rich plasma (PRP) to newborns with meningomyelocele following corrective surgery to minimize cerebrospinal fluid (CSF) leakage and accelerate the healing of the immature pouch tissue. The investigators compared these with a control group that did not receive PRP.Patients and Methods: Of the 40 newborns who were operated on with the diagnosis of meningomyelocele, 20 patients received PRP after surgical repair, and 20 were followed up without PRP. In the PRP group, 10 of the 20 patients underwent primary defect repair, the other 10 underwent flap repair. In the group that did not receive PRP, primary closure was performed in 14 patients and flap closure in six.

Eligibility Criteria

Inclusion Criteria:Newborn babies born with a meningomyelocele sacExclusion Criteria:Newborn babies without a meningomyelocele sac

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Source: ClinicalTrials.gov (NCT05711355). StuddyBuddy aggregates publicly available trial information.