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Recruiting
NCT05715203
Aortic Stiffness in Patients With Genetic Aortopathies
Conditions: Rare Diseases, Aortic Stiffness, Connective Tissue Defect
Sex: All
Enrollment: 250
Sponsor: IRCCS Policlinico S. Donato
Location: IRCCS Policlinico San Donato San Donato Milanese Lombardy
Summary
The goal of this observational study is to study arterial stiffness in patients with thoracic ascending aortic aneurysms (TAA), either syndromic or non-syndromic. The main questions it aims to answer are:
* Stratification of aortic risk based on arterial stiffness; Compare measurements with morphological and haemodynamic features of the ascending thoracic aorta.
Participants will be asked to undergo non-invasive evaluation of blood pressure and arterial stiffness.
Eligibility Criteria
Inclusion Criteria:
* Subjects with AAT, either syndromic or non syndromic;
* Signed informed consent
Exclusion Criteria:
* Patients with early menopause and/or osteoporosis, rheumatic heart disease and active malignant tumours;
* Patients with acute and chronic inflammatory conditions such as: chronic liver disease, chronic renal insufficiency and diseases affecting the thyroid system;
* Seropositivity to HIV, HCV, HBsAg and SARS-CoV-2;
* Pregnancy
Source: ClinicalTrials.gov (NCT05715203). StuddyBuddy aggregates publicly available trial information.
