Temperature on Evaporative Dry Eye

Ocular surface temperature of a normal person is around 34.6 degree centigrade. After instilling the eye drop, depending on the temperature of the eye drop and the ocular surface, the ocular surface temperature will temporally increase or decrease sightly. Warm feeling will make blood vessels dilated and more blood will pass through to bring more blood flow out of our body to the heated area of the body and makes cells more permeable. Therefore, heating the ocular surface with heated eye mask after instilling artificial tears has the possibility to improve drug permeability on the ocular surface.

Inclusion Criteria:Age ≥18 yearsThe presence of at most one symptom including burning, foreign body sensation, itching or eye fatigue for 3 monthsOSDI score ≥ 13 and TBUT <5 s or NIBUT < 10sAble and willing to comply with the treatment/follow-up scheduleExclusion Criteria:A recent history (past 30 days) of topical ophthalmic medication use, including antibiotics, steroids, non-steroidal anti-inflammatory drugs, or required the chronic use of topical ophthalmic medicationsEyelids or intraocular tumors that should not put pressureActive allergy or infection or inflammatory disease that may have prevented the subjects from completing the study at the ocular surfaceAny structural change in lacrimal passageGlaucomaDiabetes or other systemic, dermatologic, or neurologic diseases that affect the health of ocular surfaceUse of any systemic anti-inflammatory drugs or medication that may interfere with tear production, such as antianxiety, antidepressive, and antihistamine medications within 3 months