Bioavailability of Different Collagen-based Treatments After Oral Intake

The goal of this clinical trial is to investigate the postprandial absorption of collagen and elucidate the absorption rate and bioavailability after oral intake of collagen-based products. Participants will be asked to drink solutions containing the study products (one product per group, a total of four products), and blood samples will be obtained by digital puncture at different time points. Plasma will be collected and a set of collagen-derived amino acids, di-peptides and tri-peptides will be quantified by LC-MS. Each product will be compared to the placebo group.

Inclusion Criteria:Healthy male volunteers to avoid any possible hormonal interference.Between 25-45 years old (both included).Body weight is 70 kg (60-80 kg (both included), the range depends on the body mass index (BMI). BMI in normal (healthy weight and overweight) range: 18.5 to 29.9 kg/m2. (Reference: WHO and CDC).Co-operative and available during the study period.Subjects with capacity to understand the purpose and protocol of the study and sign the Informed Consent.Exclusion Criteria:- Diagnosis of allergies to gelatin, red meat (Alpha Gal Syndrome) or fish.Diagnosis of diseases about collagen metabolism such as Goodpasture syndrome, scleroderma, periarteritis nodosa or polyarteritis, dermatomyositis, and disseminated lupus erythematosus.Diagnosis of following chronic Gastro-Intestinal Tract diseases blocking transfer of polypeptides from GIS to the blood such as: Peptic Ulcer, Duodenal Ulcer, Chronic Atrophic Gastritis, Helicobacter Pylori, Chronic Peptic Disorders, Chronic Acid Reflux = GER and GERD, Celiac Disease, Crohn's Disease, Irritable Bowel Syndrome, Lactose Intolerance, Diverticulitis, Diverticulosis.Diagnosis of any diseases such as cardiovascular disease, chronic kidney disease (CKD), gastrointestinal disorder, endocrinological disorder, immunological disorder, metabolic disease.Consume more than the recommended alcohol guidelines i.e. >21 alcohol units/week for males and >14 units/week for females (europa.eu).Current smoking habit or history of smoking within the past 1 year.History of depression, schizophrenia, alcoholism, drug addiction, or mental illness.Current or previous intake of contraceptives, female hormones, obesity drugs, absorption inhibitors, antidepressants, or appetite suppressants.History of asthma or autoimmune disease Use of oral hormone therapies ie. cortisone or steroids in the 6 months prior to initiation of the study.Abnormal liver function or abnormal renal function.Blood pressure >140/90 mmHg or hypertension with intake of a diuretic.No participation to another clinical trial in the last 6 months.No blood donation within a month.Problems with overall findings in blood-test results as determined by a specialist.Any condition judged by the investigator to be unsuitable for participation in the study.