Safety and Efficacy of Two-step Radical Prostatectomy

The goal of this observational study is to learn about the safety and efficacy of two-step radical prostatectomy in the treatment of low- to intermediate-risk prostate cancer patient with enlarged prostate and severe benign prostatic hyperplasia. The main question it aims to answer are: 1. Whether two-step prostatectomy is safe enough to decrease the surgical difficulty of these patients? 2. Whether the oncologic control is promising?

Inclusion Criteria:Diagnosed as prostate cancer pathologically by prostate biopsyEvaluated as localized prostate cancer by imaging studiesProstate volume>70mL evaluated by transrectal ultrasonography or multi-parametric magnetic resonance imagingGleason score≤ 4+3=7Preoperative PSA<20ng/mLEstimated survival> 10 years；Informed consent is obtained from the patientExclusion Criteria:The patient has received other therapy including radical radiotherapy, transurethral resection of the prostate, cryoablation, HIFU, etc.Any contraindication of surgery or anaesthesia