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Not Yet Recruiting
NCT05723679
Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
Conditions: Heart Failure With Preserved Ejection Fraction, Obesity
Sex: All
Ages: 55 Years – 90 Years
Healthy volunteers: 1
Phase: EARLY_PHASE1
Enrollment: 78
Sponsor: University of Texas Southwestern Medical Center
Summary
The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity.
As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.
Eligibility Criteria
Inclusion Criteria:signs and symptoms of heart failurean ejection fraction > 0.50;objective evidence of diastolic dysfunction.
elevated biomarkers (NT-proBNP >300 ng/dl) or HF hospitalizationhealthy volunteersExclusion Criteria:age < 55 yearsBMI > 50 kg/m2Atrial fibrillation with poorly controlled heart ratephosphodiesterase type 5 (PDE5) inhibitor usesevere valvular diseasesevere Chronic obstructive pulmonary disease (COPD)Chronic kidney disease (CKD) 4 or higherany restriction of ambulation and mobility.
Source: ClinicalTrials.gov (NCT05723679). StuddyBuddy aggregates publicly available trial information.
