Singapore Lung Cancer Screening Through Integrating CT With Other Biomarkers

This is a single arm screening study. All eligible participants will be subjected to low dose CT (LDCT) screening and biomarker testing.The primary aim of the study is to determine the feasibility of conducting LDCT screening in at-risk populations for lung cancer in Singapore:For the smoker population, LDCT screening for lung cancer will be implemented in accordance to Academy of Medicine, Singapore screening test guidelines with the aim of investigating the feasibility of instituting lung cancer screening clinical service in Singapore.For the non-smoker population, LDCT screening for lung cancer will be introduced to systematically collect baseline data to better understand and provide evidence for lung adenocarcinoma in never-smoker phenotype that is unique to East Asia/Singapore. This will help address unmet needs in local population research as reported by Academy of Medicine, Singapore, to validate risk factors and inform future screening guidelines for the at-risk population.Screening results will be reported based on Lung CT Screening Reporting & Data System (Lung-RADS).

Inclusion Criteria:Smoker:Participant is willing and able to give informed consent for participation in the studyMale or female, aged 55-74 years of ageNo prior history of cancerECOG 0/1Current or former smokers with at least 30 pack years of smoking historyWilling to comply with study follow-up schedule and testsWilling to cover the costs of downstream standard of care management and investigations including doctor's fee, CT scan and biopsy etc.A Singapore citizen/Permanent Resident of SingaporeNon-Smoker:Participant is willing and able to give informed consent for participation in the studyMale, or female, aged 55-74 years of ageNo prior history of cancerECOG 0/1Never smoker, or has smoked less than 10 pack-years and has quit smoking for at least 15 yearsFamily history of lung cancer up to 2nd degree relativesWilling to comply with study follow-up schedule and testsWilling to cover the costs of downstream standard of care management and investigations including doctor's fee, CT scan and biopsy etc.A Singapore citizen/Permanent Resident of SingaporeExclusion Criteria:Uncontrolled medical comorbidity on enrolmentPrevious diagnosis of cancerBleeding diathesis that will preclude blood samplingFear of blood draw or needlesPregnancy