This Research is Conducted to Study the Effectiveness of Epidermal Growth Factor Serum in Improving Facial Skin Hydration, Elasticity, Pigmentation, and Wrinkles, Comparing Results Between Pre- and Post-application of the Serum at the Institute of Dermatology, Thailand.

EGF is a polypeptide that promotes cell differentiation and collagen production while decreasing melanin production. This study is designed to study its effectiveness in improving the texture and appearance of facial skin after daily topical application. We hypothesized that EGF would improve facial skin hydration, elasticity, pigmentation, and wrinkles.

Inclusion Criteria:ThaiMild to moderate facial skin condition, as measured by 1-2 points on the hyperpigmentation status scale or 2-3 points on the wrinkle severity grading scale.Exclusion Criteria:Use of lotions or skin care products containing ingredients such as vitamin A/C, hydroquinone, or anti-aging agents.SunbathingHypersensitivity to serum componentsPregnancy and breast-feedingActive skin diseases such as eczema or atopic dermatitis at the application site