An Evaluation of Salivary Oxidant and Antioxidant Levels in... | Clinical Trial | StuddyBuddy@endsection An Evaluation of Salivary Oxidant and Antioxidant Levels in Peri-implant Health and Disease
Join us at Health Research Day — June 6th at Canton Waterfront Park, Baltimore!   Learn More →
← Back to all trials
Completed NCT05724706

An Evaluation of Salivary Oxidant and Antioxidant Levels in Peri-implant Health and Disease

Conditions: Peri-Implantitis, Bone Loss in Jaw, Dental Implant Failed, Dental Implant Failure Nos, Oxidative Stress

Sex: All
Ages: 18 Years – 67 Years
Healthy volunteers: 1
Enrollment: 88
Sponsor: Biruni University

Summary

Objectives: Inflammatory lesions develop in the tissues surrounding implants are referred to as peri-implant diseases. Oxidants, play a role in inflammatory lesions. The study aimed to determine oxidant and antioxidant levels in the saliva of patients with various levels of peri-implant diseases and the relationship between oxidative stress and peri-implant diseases.Material and methods: Sixty-seven patients with at least one dental implant applied in our clinic were included in the study. The patients were divided into 3 groups; with peri-implantitis (PI), with marginal bone loss (MBL) and with healthy peri-implant (HI) tissues. Twenty-one individuals who didn't have any dental implants were included the study as a healthy control group (HC). For oxidant concentration, total oxidant status (TOS), advanced oxidation protein products (AOPP), and for antioxidant concentration, total antioxidant status (TAS), were investigated.

Eligibility Criteria

Inclusion Criteria:Adults aged 18 and older;Being systemically healthy; ,Being non-smokers;For dental implant groups, at least 1 osseointegrated implant;Dental implant applied by at least a specialist-level physician;Dental implants having the same surface and the same design;Correct prosthetic restoration of occlusal loading;Dental implant having been in function for at least 6 months.Exclusion Criteria:Any history of medical conditions;Presence of active periodontal disease;Use of antibiotic or anti-inflammatory medications in the past 3 months;Pregnancy;Use of AO supplements;Smoking;Poor oral hygiene;Inflammation in the oral area;Presence of active caries;Presence of oral mucosal lesions such as oral lichen planus or recurrent aphthous stomatitis.

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05724706). StuddyBuddy aggregates publicly available trial information.