Fluid Challenge and Plasma Volume, During Surgery

A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique. The purpose with the study is to examine the plasma expanding effect of three different fluid challenge strategies (acetated Ringers 4 ml/kg body weight, albumin 5% 4 ml/kg body weight or albumin 20% 1 ml/kg body weight), using hemoglobin as a dilution indicator.

Inclusion Criteria:Written consent to participate in the studyFor women: relevant contraceptive, menopausal or a negative pregnancy test.ASA category I to IIILaparoscopic abdominal surgery, with a duration of at least 90 minutes.18 to 80 yearsExclusion Criteria:Patients with known cardiac failure<18 or >80 yearsknown allergy to albuminextracellular hyperhydration or hypervolemiakidney failurepregnancy or planned pregnancy