Volatilomic Approaches for the Study of CFTR Modulators (VOLATIL-CF)

This study relies on the hypotheses that (1) exhaled breath is intimately correlated to the patient's lung condition and that (2)the composition of exhaled breath , i.e. the VOCs profile, will be significantly modified from the first days of treatment by CFTR modulators in a or pauci/symptomatic patients such as young children under 12 years old. The non-invasive and longitudinal collection and analysis of exhaled breath may reveal modifications in signaling pathways impacted by these treatments on the very short term. This study is a single-center pilot study.

Inclusion Criteria: * Patients with cystic fibrosis initiating Kaftrio® treatment. * Patients and holders of parental authority not opposing participation in this research. * Patients affiliated to a Health Insurance system or beneficiaries. Exclusion Criteria * Patients deprived of liberty or under guardianship. * Pregnant or breastfeeding patients. * Lung transplanted patients.