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Not Yet Recruiting NCT05727241

Three-dimensional Umbilical Cord Coiling Index

Conditions: Umbilical Cord Issue, Intrauterine Growth Restriction, Fetal Distress

Sex: Female
Ages: 18 Years – 45 Years
Healthy volunteers: 1
Enrollment: 250
Sponsor: Western Galilee Hospital-Nahariya

Location: Israel

Summary

Previous studies have shown that abnormal coiling of the umbilical cord is associated with adverse perinatal outcome. For example, an umbilical cord that is non-coiled increases the chance of fetal morbidity and mortality, moreover, they have shown that the lack of the usual coiled umbilical cord configuration may result in an umbilical cord that is structurally less able to withstand external mechanical stress, on the other hand, studies from recent years show that hypercoiling - excessive coiling of the umbilical cord is associated with poor obstetric outcomes, such as fetal distress at birth, meconium staining, fetal acidosis, premature birth, intrauterine growth disorder and even fetal death.The studies carried out on the calculation of UCI include performing these measurements in two dimensions, including Doppler activation, but no studies were carried out in which three dimensions were used. The purpose of the study is to measure UCI using a 3D method in a random sample of 250 patients beyond 24 week of gestation, and to compare pregnancies with hypercoiling, hypocoiling or with a normal number of coils in terms of birth outcomes.

Eligibility Criteria

Inclusion Criteria:Singleton pregnancyPregnancy week > or = 24.0Exclusion Criteria:Twin pregnancyPregnancy week<24Single umbilical cordInsufficient prenatal careAbnormal anatomical fetal findings, abnormal results of aneuploidy screeningPremature rupture of membranesPolyhydramnios or Oligohydramnios at the time of recruitment.Intrauterine growth restriction at the time of recruitment

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Source: ClinicalTrials.gov (NCT05727241). StuddyBuddy aggregates publicly available trial information.