Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases

Assessment of cardiovascular disorders using echocardiography and arterial stiffness; comparative noninvasive assessment of volatile organic compound (eVOC) exhale breath patterns in patients with different chronic respiratory diseases with age and gender-matched healthy adults in order to identify a disease-specific exhaled eVOCs profiles and markers of respiratory and cardiovascular disorders.

Inclusion Criteria:Written informed consent to participate in the study;Age 18 and over;Clinical diagnosis of one of chronic respiratory diseases (COPD, bronchial asthma, cystic fibrosis, lymphangioleiomyomatosis, hypersensitivity pneumonitis or other interstitial lung disease).Exclusion Criteria:Unable to sign informed consent;Respiratory disease (for controls);Mental illness (severe dementia, schizophrenia, severe depression, manic-depressive psychosis);Acute coronary syndrome, acute cerebrovascular accident, pulmonary embolism within the last 3 months;Oncology;Previous lung transplantation (for patients with respiratory diseases);Diseases and conditions that can change the ECG picture and complicate the analysis of the ECG (conduction disturbance, pacemaker);Inability to use a heart monitor (congenital developmental anomalies, traumatic amputation of the upper limbs, essential tremor, Parkinson's disease);Pregnancy.