Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)

The goal of this clinical trial is to evaluate the effect of transcutaneous spinal cord stimulation on blood pressure in individuals with an acute spinal cord injury (within 30 days of injury). Blood pressure instability, specifically orthostatic hypotension (a drop in blood pressure when moving lying flat on your back to an upright position), appears early after the injury and often significantly interferes with participation in the critical rehabilitation time period.The main questions it aims to answer are:Can optimal spinal stimulation increase blood pressure and resolve orthostatic symptoms (such as dizziness and nausea) when individuals undergo an orthostatic provocation (a sit-up test)? Optimal stimulation and sham stimulation (which is similar to a placebo treatment) will be compared.What are the various spinal sites and stimulation parameters that can be used to increase and stabilize blood pressure to the normal range of 110-120 mmHg?Participants will undergo orthostatic tests (lying on a bed that starts out flat and then moved into an upright seated position by raising the head of bed by 90° and dropping the base of the bed by 90° from the knee) with optimal and sham stimulation, and their blood pressure measurements will be evaluated and compared.

Inclusion Criteria:7-30 days after injuryInjury level ≥T2 (thoracic level)American Spinal Injury Association Impairment Scale (AIS) A-CExhibits at least one of the following hypotensive symptoms:Baseline hypotension - resting supine or seated SBP < 90mmHg;SBP drop ≥ 20 mmHg within 5 minutes of assuming seated position;Symptoms of orthostasis with a drop of SBP (<90mmHg) from supine to sitting.Exclusion Criteria:Current illness (e.g., a recent diagnosis of a deep vein thrombosis (DVT) or pulmonary embolism (PE), a pressure injury that might interfere with the intervention, etc.) or infectionVentilator-dependentHistory of implanted brain/spine/nerve stimulatorsCardiac pacemaker/defibrillator or intra-cardiac linesSignificant coronary artery or cardiac conduction disease, a recent history of myocardial infarctionInitiated on new cardiac medications within the past 5 daysInsufficient mental capacity to understand and independently provide consentPregnancyCancerDeemed unsuitable by study physician