The Effects of Intermittent Hypoxia on Acute Hypoxic Injury

This study intends to further reveal the effectiveness of intermittent hypoxia in preventing acute hypoxic injury.

Inclusion Criteria:Informed written consent from the volunteers.Healthy volunteers between ages of 18 and 45 years, body mass index (BMI) of 19.0 and 24.9 kg/m2.Long-term residence at flatland (altitude of <100 m), not having been to an altitude ≥1500 m in 30 days.Resting peripheral oxygen saturation of more than 90%, cerebral oxygen saturation between 58%-82%, heart rate between 60 bpm and 100 bpm, and blood pressure within the normal range (90-130/60-80 mmHg).Exclusion Criteria:History of cardiovascular, cerebrovascular, pulmonary, hepatic, dermatologic, or hematologic diseases.History of substance abuse.The use of medications or medical devices.Pregnancy, hypertension, diabetes mellitus, obesity, sleep apnea and neurological disorders.