Phase II Clinical Trial to Evaluate the Efficacy and Safety of SCAI-001 Eye Drops in Patients With Dry Eye Disease

This study is planned to Evaluate the Efficacy and Safety of SCAI-001 Eye Drops(Cyclosporine 0.01%, 0.02%) in Patients with Dry Eye Disease.

Inclusion Criteria:Male and Female who over 19 years oldDry eye symptoms (Dryness, Grittiness, soreness, irritation, watering, etc.)Those who meet below criteria at least one of two eyes;Those who have over than score 2 in corneal staining test-Oxford gradingTear secretion test without anesthesia(Schirmer test) result would be under 10mm/5min (If the test result is 0mm/5min, it should be over than 3mm/5min on the nasal stimulation schirmer test in the same eye)TBUT(Tear film break-up time) test result should be under 10sec.The corrected visual acuity is 0.2 or moreExclusion Criteria:Those who have clinically significant eye disease not related to dry eye symdromeThose who are in medication of systemic steroid or immunosuppressant 90days before screening visitThose who have worn contact lenses before 72hours or have to wear contact lenses or disagree not to wear contact lenses during study periodThose who have medical history with intraocular surgery 12months before screening visitThose who have diagnosed with glaucoma or have an intraocular pressure over than 21mmHg at least in one of the eyesThose who have medicated cyclosporine eye-drops 6weeks before screening visitThose who have underwent any eye correction surgery such as LASIK(Laser-assistant in situ keratomileusis) 12 months before screening visitThose who have underwent a silicone lacrimal punctal occlusion or cauterization of the punctum excluding collagen lacrimal punctal occlusion 90 days before screening visitThose who have received other investigational drugs/devices 30 days before screening visit