Colchicine Protective Effect in Patients Undergoing Percutaneous Coronary Intervention (COLCHICINE-PROTECT)

The goal of this clinical trial is to evaluate the colchicine protective effect in patients undergoing Percutaneous Coronary Intervention (PCI). The main question it aims to answer is: does initiating colchicine before planned PCI will reduce post-procedural myocardial injury? Half of the participants will receive colchicine, while the other half will receive a placebo.

Inclusion Criteria:Chronic Coronary Syndrome (CCS) participants referred for PCI.Acute Coronary Syndrome (ACS) participants who are medically treated or undergoing revascularization for non-culprit lesions will be included if their troponin I and hs-CRP returned back to normal baselineExclusion Criteria:Acute Coronary Syndrome (ACS) participants.Chronic kidney disease (glomerular filltration rate <30 ml/ min).Participants with history of cirrhosis.Participants on systemic immunosuppressive or corticosteroid therapy.Active malignancy or infection.Elevated troponin I.