Key circRNA Identification of Postoperative Delirium in Elderly Patients Undergoing Cardiac Surgery

We further propose the study of circRNA in the occurrence and development of POD. To better understand the potential role of circRNA in the pathological mechanism of POD through clinical trials, and to discover key circRNA as a biomarker for early prevention and early diagnosis of POD. It provides a new idea and new target for the prevention and treatment of POD. In order to minimize the impact of POD on the prognosis of elderly patients, it has important theoretical significance and clinical value.

Inclusion Criteria:Be over 50 years old;ASA Grade I-III;Heart surgery is planned under general anesthesia.Exclusion Criteria:Patients with the second surgery;The ejection fraction is less than 40%;The score of the preoperative simple mental status examination (MMSE) is less than 24 points;Patients with mental illness or central nervous system disease;Patients who cannot or refuse to complete MMSE before surgery.