Normothermic Machine Perfusion (NMP) Versus Hypothermic Machine Perfusion (HMP) in Human Kidney Transplantation

Due to the rising incidence of renal failure and the improvement of organ transplantation technology, the shortage of donor organs has become one of the main problems limiting the development of kidney transplantation. Marginal donor is one of the important ways to extend the donor pool. Normothermic mechanical perfusion (NMP) is a new generation of organ preservation technology, which can maintain the blood supply and at the same time evaluate the marginal kidney function during the organ preservation. However, the clinical effect has not been proved. Hypothermic Machine Perfusion (HMP) is the mainstream organ perfusion technology. This study aims to compare the effectiveness of NMP with the HMP.

Inclusion Criteria:Age 18-60 years old, gender unlimitedVolunteer to participate in this clinical trial and sign the informed consent formSuffering from end-stage renal diseasePlanned kidney transplantationThe expanded standard donors (ECD) were obtainedThe expanded standard kidney donor is defined as: aged cadaver donors over 60 years old or two or three of the following conditions between 50 and 60 years old: death due to cerebrovascular disease; Hypertension; The blood creatinine level before donation was greater than 133umol/L.Exclusion Criteria:Active infectionLiving donor kidney recipientAcute rejectionSecond kidney transplantationCombined transplantation (combined liver and kidney, combined pancreas and kidney)Patients who take other clinical trial drugs or participate in other clinical studiesUnable to continue the researchPatients who are judged by the researcher to be unsuitable for this clinical trial