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Completed
NCT05797649
Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)
Conditions: Pleural Effusion, Heart Failure, Malignant Neoplasm, Fluid Overload, Hypoalbuminemia, Renal Failure, Cirrhosis, Infections
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Enrollment: 160
Sponsor: Chinese University of Hong Kong
Location: Prince of Wales Hospital Hong Kong New Territories
Summary
To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).
Eligibility Criteria
Inclusion Criteria:
* Patients hospitalized for heart failure and pleural effusion
* Pleural tapping indicated for pleural fluid analysis.
* Aged 18 years old or above
Exclusion Criteria:
* History of intrapleural therapy (including talc and fibrinolytic) in the ipsilateral pleural space.
* History of surgical decortication or pleurodesis in the ipsilateral pleural space.
* Ipsilateral thoracic or cardiac surgery in the past 3 months.
* Failure to obtain informed consent due to the patient's refusal or cognitive impairment.
Source: ClinicalTrials.gov (NCT05797649). StuddyBuddy aggregates publicly available trial information.
