EPI-MINN: Targeting Cognition and Motivation - National

The purpose of this study is to perform a practice-based research project designed to assess whether cognition and motivated behavior in early psychosis can be addressed as key treatment goals within real-world settings by using a 12-week mobile intervention program. We will recruit participants who are receiving care for early psychosis from clinics across the United States. We will compare outcomes from participants who receive treatment at coordinated specialty care (CSC) early psychosis clinics to those that receive standard community care. A qualifying CSC program will provide comprehensive clinical services such as psychotherapy, medication management, psychoeducation, and work or education support. This study will be conducted remotely, and participants can participate at home with their own electronic devices. The aim of this study is to investigate a well-defined 12-week mobile intervention program specifically designed to target cognitive functioning and motivated behavior for individuals with early psychosis. Participants will complete a screening interview which will include diagnosis and symptom ratings, neurocognitive assessment, and self-reports of symptoms, behavior, and functioning. Then participants will be randomized to receive the 12-week mobile intervention, or an active control of treatment as usual. The investigators will test for differences in the clinical trajectories after training, and at two follow up appointments at 6 and 12 months post-training.

Inclusion Criteria: * Aged 15-40 (inclusive) * Is enrolled in an early psychosis coordinated specialty care clinic, or is receiving services by a mental health care professional. * Symptoms of psychosis started within the last 5 years * Is in good general physical health (e.g., not acutely ill or experiencing a sever/chronic illness that would impede their ability to complete study activities) * Fluent in spoken and written English * Estimated IQ at or above 70, as estimated by the Test My Brain matrices task * Participants will show overall clinical stability as determined by interview measures. Generally, participants who have not been hospitalized within the last 30 days, who have not had significant changes to medications, and do not have active suicidal ideation will be considered stable. * Has access to a smart phone or other mobile device to use the PRIME App * Has access to a computer or tablet to complete cognitive training exercises and study assessments Exclusion Criteria: * Unable to provide informed consent (i.e., cannot pass UBACC assessment) * Participant is under legal commitment to treatment or is under medical guardianship * Participated in significant cognitive training programs within the last 3 years * Diagnosed with a neurological disorder that may interfere with participation in the study * Clinically significant substance abuse that is impeding the participant's ability to participate fully during enrollment, assessment, or training (i.e., is unable to remain sober) * Risk of suicidal behavior