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NCT05933707
Small Extracellular Vesicles and Insulin Action
Conditions: Obesity, Insulin Resistance, Metabolically Healthy Obesity, Obesity, Metabolically Benign
Sex: All
Ages: 25 Years – 55 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 72
Sponsor: Washington University School of Medicine
Location: Washington University School of Medicine St Louis Missouri
Summary
The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop obesity-related conditions; 2) assess the effect of small extracellular vesicles (sEVs also called exosomes), obtained from human participants, on metabolic function in cultured cells and in mice.
Eligibility Criteria
Inclusion Criteria:
* Metabolically healthy lean subjects must have a BMI ≥18.5 and ≤24.9 kg/m²; Subjects with obesity must have a BMI ≥30.0 and ≤50.0 kg/m²
* Metabolically healthy lean and people with metabolically healthy obesity must have intrahepatic triglyceride (IHTG) content ≤5%; fasting plasma glucose concentration \120 min/week),
* Are pregnant or lactating
Source: ClinicalTrials.gov (NCT05933707). StuddyBuddy aggregates publicly available trial information.
