Southeastern ATTR Amyloidosis Consortium: SEATTRAC Family Registry

The study design is a prospective registry including asymptomatic and symptomatic patients who carry a pathogenic TTR mutation. The study will enroll patients who meet the inclusion criteria and none of the exclusion criteria until 1000 patients are enrolled, at which point in time the study investigators will evaluate whether further patient accrual is meaningful.

Inclusion Criteria: * Over the age of 18 years * Carrier of a pathogenic hATTR mutation confirmed on whole blood gene testing or mass spectrometry * Willing to return for required follow-up visits Exclusion Criteria: * Patient having undergone heart transplantation or implantation of mechanical circulatory support * Patients unable to provide informed consent * Patients having undergone liver transplantation * Patients have evidence of light chain amyloidosis