Magnetic Resonance Imaging (MRI) and Eye-tracking Predictive Markers of Cognitive Ageing.

This research proposes to investigate physiological and cognitive markers of locus coeruleus (LC) neuronal integrity and function in cognitively-healthy participants over 60 years old. The locus coeruleus is a brainstem nucleus, sole source of noradrenaline for the brain. Tau pathology appears in neurons of this nucleus, which may induce initial cognitive changes. The study aims at relating locus coeruleus markers, assessed with MRI and eye-tracking techniques, with cognitive function.

Inclusion Criteria: * INSPIRE cohort participant * Mini-Mental State Examination score ≥ 27 on 30 * Access to a web connection from participant's or relative's home and regular use of web surfing * Signature of the informed consent * Affiliated to a social security scheme Exclusion Criteria: * Any contra-indications to MRI exam * Ophthalmic pathology impacting eye-tracking measures * Neurological or psychiatric pathology * Person under guardianship or curatorship Contraindications to MRI examination: * Pacemaker or cardiac defibrillator * Implanted material activated by an electrical, magnetic or mechanical system * Haemostatic clips for intracerebral aneurysms or carotid arteries * Orthopedic implants * Claustrophobia Ophthalmological pathologies impacting eye tracking measurements: * Glaucoma * Age-related macular degeneration * Unoperated cataract