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NCT06092814
tACS to Enhance Language Abilities
Conditions: Stroke, Aphasia, Acquired, Aphasia
Sex: All
Ages: 18 Years – 85 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 120
Sponsor: University of Pennsylvania
Location: University of Pennsylvania Philadelphia Pennsylvania
Summary
The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aphasia group with aged matched controls to see if brain response to tACS differs between groups.
Eligibility Criteria
Inclusion Criteria for Persons with Aphasia:
1. Presence of aphasia
2. Suffered a single, left hemisphere stroke
3. Stroke ≥6 months old (chronic) at the time of enrollment
Inclusion Criteria for Healthy Controls:
1. Right-handedness
2. Must be able to understand the nature of the study, and give informed consent
Exclusion criteria for Persons with Aphasia:
1. Inability to understand the nature of the study
2. Marked naming impairment
3. Impaired non-verbal, conceptual processing
4. History of significant medical or neurological disorder (other than stroke)
5. History of significant or poorly controlled psychiatric disorders
6. Current abuse of alcohol or drugs, prescription or otherwise
7. Nursing a child, pregnancy, or intent to become pregnant during the study
8. Clinically significant hearing loss
9. Contraindications to tACS
10. Contraindications to MRI
Exclusion Criteria for Healthy Controls
1. Diagnosis of a neurodegenerative disease or clinically significant cognitive complaint
2. Any unrelated neurologic or physical condition that impairs communication ability
3. History of unrelated neurological conditions including but not limited to traumatic brain injury, stroke, or small vessel disease that has resulted in a neurologic deficit
4. Any additional neurological condition that would likely reduce the safety of study participation, including central nervous system (CNS) vasculitis, intracranial tumor, intracranial aneurysm, multiple sclerosis or arteriovenous malformations
5. A medically unstable cardiopulmonary or metabolic disorder
6. Terminal illness associated with survival \
Source: ClinicalTrials.gov (NCT06092814). StuddyBuddy aggregates publicly available trial information.