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Recruiting
NCT06096259
Preventing Injured Knees From osteoArthritis: Severity Outcomes
Conditions: Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
Sex: All
Ages: 18 Years – 45 Years
Healthy volunteers: No
Phase: PHASE2
Enrollment: 512
Sponsor: Brigham and Women's Hospital
Location: Emory University Atlanta Georgia
Summary
This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction. This research study will compare metformin to placebo. The placebo tablet looks exactly like metformin, but contains no metformin. Placebos are used in research studies to see if the results are due to the study drug or due to other reasons.
Metformin is approved by the U.S. Food and Drug Administration (FDA) to treat type II diabetes. Notably, it also has anti-inflammatory effects, suggesting it could benefit people who have an ACL injury and are undergoing ACL reconstruction.
Eligibility Criteria
Inclusion Criteria:
1. Age 25-45 or Age 18-24 with preoperative KOOS Pain \
Source: ClinicalTrials.gov (NCT06096259). StuddyBuddy aggregates publicly available trial information.
