Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

The purpose of this study is to find out if performing additional Magnetic Resonance Image (MRI) scans of the subjects' brain during each week of the radiation treatment of their high-grade glioma will help improve the radiation treatment.

Inclusion Criteria: * Histopathologically proven diagnosis of glioblastoma, anaplastic astrocytoma, or anaplastic oligodendroglioma * History and physical examination within 28 days prior to enrollment * Karnofsky performance status 70 or greater * Age 18 years or greater * Negative pregnancy test for females of childbearing potential before 1st research MRI, performed in accordance to institutional guidelines. * Plan to receive standard of care 59.4-60 Gy in 30-33 fractions of radiotherapy. Glioblastoma patients over 65 year-old can receive standard of care hypofractionated radiotherapy including 40 Gy in 15 fractions. Exclusion Criteria: * Prior therapy for tumor except for biopsy or resection, including prior radiotherapy to the brain. * Clinical or radiological evidence of metastatic disease outside the brain * Prior malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 2 years