Optimal Stimulation Parameters to Disrupt Epileptiform Activity

Open-loop electrical stimulation has been found to reduce spike activity and seizures, but determining the optimal parameters to achieve these effects requires a brute force trial-and-error approach that relies on subjective physician discretion. We compared the performance of stimulation parameters identified in rodent models to the recommended parameters for neuromodulation used in clinical practice.

Inclusion Criteria: * Undergoing intracranial EEG investigation at Massachusetts General Hospital during presurgical epilepsy evaluation. * Consented for stimulation experiment. Exclusion Criteria: * Baseline spike ripple rate \< 0.5/min. * Did not complete 3 hours of stimulation.