Impact of Gravity on Cardiac Hemodynamics

The goal of this clinical trial is to define and compare pre-load dependance of the cardiac function according to the intracardiac hydrostatic gradient of pressure in healthy and diabetic populations. Participants will undergo 4 tilt angle and 4 lower body negative pressure intensities during which cardiovascular data will be assessed and a transthoracic echography will be performed.

Inclusion Criteria: * Affiliated to the social security system * Patient informed of the study and having signed an informed consent form * Type 1 diabetes for at least 10 years followed at Caen University Hospital, equipped with a continous glucose monitoring system Exclusion Criteria: * Trained athletes (≥ 6 hours of sustained physical exercise \>70% VO2max per week for \> 6 months) * Chronic cardiovascular disease or cardiovascular treatment * Personal history of chemotherapy and/or thoracic radiotherapy * Cerebral and/or spinal disease * Inclusion of the subject in another biomedical research protocol of interventional type (during the study or in the 3 months prior to inclusion) * Pregnant, breast-feeding or parturient women * Adults under legal protection (guardianship, curators) or unable to express their consent or deprived of their freedom