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Recruiting
NCT06223828
Azithromycin for Critical Asthma - Pediatrics
Conditions: Pediatric Asthma, Critical Illness
Sex: All
Ages: 3 Years – 17 Years
Healthy volunteers: No
Phase: PHASE2, PHASE3
Enrollment: 100
Sponsor: Johns Hopkins All Children's Hospital
Location: Johns Hopkins All Children's Hospital St. Petersburg Florida
Summary
The CR-AZI Study will assess the immunomodulatory effects of Azithromycin for pediatric Critical Asthma.
Eligibility Criteria
Inclusion criteria
* Age 3-17 years
* Admission to the PICU
* Primary diagnosis of critical asthma
* Prescription for continuous inhaled beta-agonist therapy and/or intravenous (IV) beta-agonist therapy
* Prescription for intravenous systemic corticosteroids
Exclusion criteria
* Critical Congenital Heart Disease Unrepaired
* Tracheostomy Dependence at Admission
* Ongoing Exposure to Azithromycin or Macrolide Antibiotics for any indication
* Past Medical History of Prolonged QT Syndrome or Arrhythmias
* Concomitant respiratory pathology including Acute Chest Syndrome, Interstitial Lung Disease, Cystic Fibrosis, and pulmonary hypertension
Source: ClinicalTrials.gov (NCT06223828). StuddyBuddy aggregates publicly available trial information.
