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Active Not Recruiting NCT06295757

Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures

Conditions: Tobacco Use, Cigarette Smoking, Nicotine Dependence

Sex: All
Ages: 21 Years – N/A
Healthy volunteers: Yes
Phase: NA
Enrollment: 26
Sponsor: Masonic Cancer Center, University of Minnesota

Location: Irina Stepanov, PhD Minneapolis Minnesota

Summary

Characterize effects of relighting on smoke toxicant deliveries and subjective smoking measures. This will be a within-subject comparison in a single experimental group of 30 smokers who report engaging in relighting behaviors. We will assess smoking intensity for relit and non-relit (i.e., smoked continuously without relighting) cigarettes in the natural environment and will conduct in-clinic measurements of smoking topography and subjective responses for relit and non-relit cigarettes. Information on relighting patterns and smoking topography collected from each participant will be used to compare machine-measured smoke yields of key harmful constituents when their usual cigarettes are smoked with and without relighting. Hypothesis: Relit cigarettes will produce higher levels of toxicants than non-relit cigarettes.

Eligibility Criteria

Inclusion Criteria: * Smoking at least 10 cigarettes/day for at least 1 year (confirmed by CO \> 8 ppm or NicAlert test of 6) * Engaging in relighting for at least half of their CPD * No smoking quit attempts in the past month nor intentions to quit in the next month * Stable medical or psychiatric conditions with systolic blood pressure \< 160, diastolic blood pressure \< 100 and heart rate \< 105 bpm Exclusion Criteria: * Participant with current or recent alcohol or drug abuse problems, use of substances of abuse (other than marijuana due to high prevalence of co-use) within the past month * Currently trying or planning to quit smoking in the next month * Planning to become pregnant, pregnant or breastfeeding. Pregnancy exclusion will be confirmed through a urine test.

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Source: ClinicalTrials.gov (NCT06295757). StuddyBuddy aggregates publicly available trial information.