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Recruiting NCT06386588

The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia

Conditions: Schizophrenia

Sex: All
Ages: 18 Years – 45 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 60
Sponsor: Massachusetts General Hospital

Location: Massachusetts General Hospital Charlestown Massachusetts

Summary

In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights. On some nights the headbands will play soft sounds at specific times during sleep. The investigators are interested in learning whether this timed auditory stimulation may be a strategy to improve the coordination of sleep rhythms across brain regions, improve network communication, and as a result, improve memory. The investigators will study 30 adults aged 18-45 with schizophrenia and 30 demographically matched healthy controls. Participants will first have a daytime MRI scan, during which they will complete a finger tapping motor sequence task (MST), followed by a week of sleep at home with a sleep headband. They will also do the MST at home on two of the nights. On the final day of the study, participants will return for a second MRI scan.

Eligibility Criteria

Inclusion Criteria: * 18-45 years old * Fluent in English * Able to give informed consent Additional inclusion for Adults with schizophrenia: * A DSM-V confirmed diagnosis of schizophrenia * Unmedicated or maintained on a stable dose of APDs Exclusion Criteria: * Ferrous metal in the body * Currently pregnant or breastfeeding * Motor problems that preclude finger tapping task * IQ \

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT06386588). StuddyBuddy aggregates publicly available trial information.