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Recruiting
NCT06396416
Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2
Conditions: Obesity, Chronic Kidney Disease
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: PHASE4
Enrollment: 60
Sponsor: Western University, Canada
Location: London Health Sciences Centre London Ontario
Summary
OK-TRANSPLANT 2 is a vanguard study for a large randomized, pragmatic, open-label trial.
We will randomize participants with obesity, high-risk CKD/dialysis who are hoping for lose weight for the purpose of kidney transplant. Subjects will either be enrolled on a virtual weight management program or continue their usual care.
Eligibility Criteria
Inclusion Criteria:
* Adults aged 18 years or older
* BMI; 35 kg/m\^2
* 10% risk of ESKD requiring renal replacement therapy over 2 years or receiving dialysis
Exclusion Criteria:
* Known contraindication to a GLP-1RA (pancreatitis, personal or family history of medullary thyroid cancer, hypersensitivity)
* Type 1 diabetes
* No access to semaglutide via drug coverage
* Pregnant, breastfeeding or planning to become pregnant
* Currently in a GLP-1RA or GLP-1RA/GIP study or planning to be in one
Source: ClinicalTrials.gov (NCT06396416). StuddyBuddy aggregates publicly available trial information.
