Identifying Individuals at Risk of Glucocorticoid-Induced Impairment of Bone Disease

Sex: All

Ages: 18 Years – 50 Years

Healthy volunteers: Yes

Phase: PHASE2

Enrollment: 36

Sponsor: Odense University Hospital

Summary

Previous studies have shown that there is a large inter-individual variability in the degree of bone loss during glucocorticoid treatment, and while some patients experience extensive bone loss other patients\' bone mass remains stable. The aim of the study is to find a biomarker that can be used to identify individuals at risk of glucocorticoid-induced bone loss. The study will include 36 healthy volunteers, that will be randomized to receive either glucocorticoid treatment or placebo. During the study blood samples, bone marrow samples, bone tissue samples, and adipose tissue samples are taken and an oral glucose tolerance test is performed.

Eligibility Criteria

Inclusion Criteria: * Men and women aged 18-50 years. Exclusion Criteria: * Uncontrolled thyrotoxicosis * Chronic kidney disease (eGFR \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT06421597). StuddyBuddy aggregates publicly available trial information.