Bioavailability and Bioactivity of Orange Polyphenols

This study will provide a greater insight into the relationship between orange consumption and health (particularly gut health) and could be used to help with the development of novel food products. Oranges are a rich source of (poly)phenols, and although the advantages of a (poly)phenol-rich diet are well-established, the bioavailability and bioactivity of orange (poly)phenols in the context of human digestion are poorly understood. This study will address this gap in research.

Inclusion Criteria: (ileostomates) * Adult with an ileostomy, ≥1.5-years post-operative * Aged 18-75 years at recruitment * Not pregnant / lactating * No learning or other disabilities * Not currently taking antibiotics * Not currently taking plant-based dietary supplements * Not currently taking any prescribed medications that would prevent overnight fasting Inclusion Criteria Healthy adults; no pre-existing chronic disease (GI related) * Aged 18-75 years at recruitment * Not pregnant / lactating * No learning or other disabilities * Not currently taking antibiotics * Not currently taking plant-based dietary supplements * Not currently taking any prescribed medications that would prevent overnight fasting Exclusion criteria (Ileostomates): * Adults \75 years at recruitment * Ileostomy, \