Magnetic Resonance Fingerprinting Guided Extended Resection in Glioblastomas

Magnetic resonance imaging, MRI, is a procedure that uses radio waves, a powerful magnet, and a computer to make a series of detailed pictures of areas inside the body. The goal of this study is to determine if MR fingerprinting, new way of acquiring MRI images, can help identify the extent of tumor spread in the brain, better than routine MRI images.

Stage I: Inclusion criteria: * Age \> 18 * MR imaging findings suggestive of GB * Maximal tumor diameter greater than 3 cm * Ability to provide written informed consent * Ability to undergo MRI scan * Consideration for biopsy, subtotal or gross total resection. Exclusion Criteria: * Contraindications to MRI * Contraindication to surgical treatment * Prior treatment for glioblastoma Stage II: Inclusion Criteria: * Age \> 18 * MR imaging findings suggestive of GB * Maximal tumor diameter greater than 3 cm * Ability to provide written informed consent * Ability to undergo MRI scan * Lesions amenable to gross total resection * Presence of peritumoral FLAIR signal abnormality beyond the area of enhancement. Exclusion Criteria: * Inability to undergo MRI imaging * Participants undergoing only stereotactic biopsy or less than gross total resection * Participants undergoing LITT * Inability to consent for the study * Previously treated/ recurrent glioma.