Multispectral Optoacoustic Tomography in Head and Neck Squamous Cell Cancer

The purpose of this research is to assess the safety and evaluate the potential of the Multispectral Optoacoustic Tomography (MSOT) device to more precisely identify and assess the neck lymph nodes which might be affected in patients with metastatic head and neck squamous cell carcinomas.

Inclusion Criteria: * Clinically confirmed node positive head and neck squamous cell cancer * Written informed consent signed and dated by the patient prior to the performance of the MSOT * At least 18 years-of-age at the time of signature of the informed consent form (ICF) * Patients planned for curative intent therapy * Patient available for the study duration * Patients of childbearing potential must have a negative pregnancy test prior to the study entry. * Patients of childbearing potential must use an effective form of contraceptive as per the protocol. Exclusion Criteria: * History of previous head and neck radiotherapy * Intent of treatment palliative * Women who are pregnant * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety of efficacy assessment of the investigational regimen should be included. * Psychological, familial, sociological, or geographical conditions that do not permit compliance with the protocol and/or follow-up procedures outlined in the protocol.